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2015 1A1 Group 9 - Celiac Disease

Page history last edited by class1a1group9 8 years, 8 months ago

Team member

Fattah(Leader)
Adil (Editor)
Aung Pyae Sone (Researcher)

Meaning / Definition

Celiac Disease is an autoimmune disorder of the small intestine that occurs in genetically predisposed people of all ages from middle infancy onward. Symptoms include pain and discomfort in the digestive tract, chronic constipation and diarrhoea, failure to thrive (in children), anaemia^[2] and fatigue, but these may be absent, and symptoms in other organ systems have been described. Vitamin deficiencies are often noted in people with celiac disease owing to the reduced ability of the small intestine to properly absorb nutrients from food.

Meaning of words:

Autoimmune:relating to disease caused by antibodies produced against substances naturally present in the body.

Anaemia:Dificiency in red blood cells

Fatigue: Extreme exhuastion from mental or physical illness

Gluten:Gluten is

a protein composite found in wheat and related grains, including barley and rye. Gluten gives elasticity to dough, helping it rise and keep its shape and often gives the final product a chewy texture.

Causes and Effects

People who are exposed to gluten in their diet, an enzymes called tissue transglutaminase,a

synthetic that causes an immune response, leading to inflammation of the lining of the small intestine

(A transglutaminase is an enzyme that catalyzes the formation of an isopeptide bond between a free amine group)

Image result for celiac disease

Signs and Symptoms

The signs are diarrhea and weight loss.Other signs and symptoms are:

Anemia, usually resulting from iron deficiency
Loss of bone density (osteoporosis) or softening of bone (osteomalacia)
Itchy, blistery skin rash (dermatitis herpetiformis)
Damage to dental enamel
Headaches and fatigue
Nervous system injury, including numbness and tingling in the feet and hands, and possible problems with balance
Joint pain
Reduced functioning of the spleen (hyposplenism)
Acid reflux and heartburn